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Bartosz Andrzej Grzybowski
Distinguished
Professor, Department of Chemistry, UNIST Group
Leader, Center for Soft and Living Matter, Institute for Basic Science Professor, Polish Academy of Sciences |
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RESEARCH SUMMARY | | | Grzybowski
group has pioneered applications of artificial intelligence and network theory
to synthetic chemistry - this work has given rise to the creation of the
Chematica/Synthia platform for computerized retrosynthesis of complex
molecules, including natural products (Nature
2020a), as well as the Allchemy software for the discovery of new synthetic
methodologies and new functional molecules (Science
2020, Nature 2022). Our current interests in this arena focus on
computer-driven discovery of new reactions and catalysts and also on robotized
systems in which chemical AI controls and optimizes actual experiments. We are
also very active in a quest to develop "smart" systems that, in one vessel,
perform multiple chemical reactions and/or processes - for instance, multistep
synthetic cascades (Nature 2020b) or
processes (Nature 2022c). We are also
working at the intersection of molecular chemistry with nanotechnology to
develop platforms for selective catalysis (JACS
2021) as well as therapeutic warheads for selective cancer intervention (Nature Nanotech 2020). Overall, we are a
diverse crowd of chemists, physicists, and biologists and we pursue research
that we think is paradigm-shifting and/or addresses important societal needs. Our
group is a place to consider if you are passionate about science and would like
to make chemistry a truly high-tech enterprise! |
EDUCATION AND PROFESSIONAL EXPERIENCE |
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6/1995 |
B.S., Chemistry, Yale University, New Haven, CT |
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6/1995 |
M.Sc., Chemistry, Yale University, New Haven, CT |
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11/2000 |
Ph.D., Chemistry, Harvard University, Cambridge, MA |
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10/2000-7/2001 |
Postdoctoral Fellow, Harvard University |
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7/2001-8/2003 |
Director of Research, Vitae Pharmaceuticals and Associate of the Department of Chemistry and Chemical Biology, Harvard University |
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7/2002-present | Chief Scientific Officer, ProChimia Surfaces, Ltd. |
| 9/2003-8/2007 |
Assistant Professor,
Northwestern University, Department of Chemical and Biological Engineering and Department of Chemistry |
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9/2007-8/2009 |
Associate Professor,
Northwestern University, Department of Chemical and Biological Engineering and Department of Chemistry |
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7/2009-5/2017 |
President of GSI, L.L.C. |
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9/2009-12/2014 |
Director of the DoE Energy Frontier Research Center (Non-Equilibrium Energy Research Center, Northwestern
University) |
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9/2009-12/2014 |
Full Professor, Kenneth Burgess Chair in Physical Chemistry and Chemical Systems Engineering, Department of Chemical and Biological Engineering and Department of Chemistry |
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9/2014-present |
Professor, Polish Academy of Sciences |
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12/2014-present |
Distinguished Professor of Chemistry, UNIST |
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7/2015-present 5/2023-present |
IBS Group Leader, IBS Center for Soft and Living Matter @ UNIST Acting Director, IBS Center for Soft and Living Matter @ UNIST |
HONORS AND AWARDS |
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Arthur Fleischer Award for Outstanding Performance in Chemistry, Yale University (1995) |
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Honoris in Chimia, Yale University (1995) |
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Summa cum Laude, Yale University (1995) |
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Camille and Henry Dreyfus New Faculty Award (2003) |
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National Science Foundation CAREER Award (2006) |
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3M Non-Tenured Faculty Award (2006) |
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Pew Scholar in the Biomedical Sciences (2006) |
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American Chemical Society Division of Colloid and Surface Chemistry Unilever Award (2006) |
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Sloan Fellowship (2007) |
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Camille Dreyfus Teacher-Scholar Award (2007) |
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G.Kanig Award for Innovation (Verband für Polymerforschung, Germany) (2008) |
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Soft Matter Lecturership (Royal Society of Chemistry, UK) (2010) |
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Saville Lecturership (Princeton University) (2010) |
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Crano Distinguished Lectureship (American Chemical Society, Akron Section) (2010) |
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American Institute of Chemical Engineers NSEF Young Investigator Award (2010) |
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Centennial Year of Chemistry Distinguished Lecture (Wroclaw University, Poland) (2011) |
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Excellence in Nanoscience Lectureship (EPFL, Switzerland) (2012) |
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MESA Institute Annual Lecture (University of Twente, the Netherlands) (2012) |
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ISIS Distinguished Lectureship (University of Strasbourg, France) (2012) |
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Nanoscience Prize (International Society for Nanoscale Science, Computation and Engineering) (2013) |
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The Givaudan Lecture and the Bristol Synthesis Meeting (2014) |
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Fellow of the Royal Society of Chemistry (2015) |
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The Feynman Prize in Nanotechnology (2016) |
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WuXi Distinguished Lecturer (Shanghai, China) (2018) |
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Sendzimir Honorary Medal (Society of Innovators, Poland) (2019) |
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25th Solvay Conference on Chemistry (Brussels, Belgium) (2019) |
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NIH NCATS "Aspire" Award (National Institutes of Health, NIH, Washington, USA) (2019) |
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Elected Member of the Societas Scientarum Varsaviensis (Towarzystwo Naukowe Warszawskie) (2020) |
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AbbVie Discovery 2021 Platform Chemistry Technology Seminar (2021) Grand Academic Award (Academic Affairs Team, UNIST) (2020) FNP Prize (Foundation for Polish Science) (2022) Bowei Research Conference Lecture (Kending, Taiwan) (2023) Solvay Workshop on Chemistry (Brussels, Belgium) (2023) IUPAC Plenary Lecture (The Hague, The Netherlands) (2023) |
RESEARCH AREAS |
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Computerized synthesis and artificial intelligence, AI, applied to organic chemistry Discovery of new reactions and of new drugs AI for chemical waste management Complex chemical networks and catalytic systems Self-assembly in non-equilibrium regimes Energy storage Nanomaterials for catalysis and nanomedicine
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HIGHLIGHTS OF SCIENTIFIC CONTRIBUTIONS |
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Grzybowski and his team pioneered research on non-equilibrium self-assembly processes in chemical systems (Nature 2000, Science 2002a, Science 2002b, Nature 2018, Nature 2020a, Nature 2020b). They were the first ones to describe nanoscale self-assembly based on electrostatic interactions (Science 2006), and first ones to demonstrate all-nanoparticle electronics (Nature Nanotechnology 2011, 2016, Nature Materials 2012). Grzybowski's team discovered several fundamental phenomena at small scales (e.g., plastic-metals, Science 2007; inverse photoconductors, Nature 2009) and is recognized as being the pioneers of reaction-diffusion chemical systems operating in the nano- and microscopic regimes (reviewed in Angew. Chem. 2010 and also in Grzybowski's textbook on the subject). In 2011, the group solved perhaps the oldest scientific question - originally posed by Thales of Miletus - as to how and why materials charge upon contact with one another (Science 2011, Science 2013). In 2013, they have demonstrated magnetic traps that unlike their optical counterparts can manipulate nanoscopic objects, both magnetic and non-magnetic (Nature 2013). Grzybowski's most impactful discoveries are in the area of computer-planned organic synthesis and AI for reaction and drug discovery. The Grzybowski group discovered and quantified the general laws governing the Network of Organic Synthesis (Nature Chemistry 2009), and created Chematica, the "chemical brain" for the planning of organic syntheses (Angew. Chem. 2012a, 2012b, 2012c, 2016, Chem 2018,2019, 2020). In 2020, they demonstrated how computers can plan syntheses to complex natural products (Nature 2020) and how they can discover new prebiotic syntheses (Science 2020). Grzybowski has a strong track record of research commercialization. The companies he started has achieved a valuation of close to $1 billion. He also advises pharma industry (e.g., Merck) and has managed a portfolio of research grants (from US, Korean and Polish governments totaling >$40 million). Grzybowski is an
author of over 280 articles cited close ca. 20,000 times (Web of Science). Over
the years, he received several awards including NSF CAREER Award, Pew
Scholar in the Biomedical Sciences, American Institute of Chemical Engineers
NSEF Young Investigator Award, ACS Unilever Award, Sloan Fellowship, Dreyfus
Teacher-Scholar Award, Nanoscience Prize, 2016 Feynman Prize, 2020 UNIST's Grand Academic Award, and 2022 FNP Prize. |
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